Call to arms d2 base5/18/2023 ![]() Cariprazine’s beneficial effect on cognition is likely due to its affinity for D3 receptors, as well as agonism at 5-HT1A receptors. Cariprazine improves learning, recognition, and spatial memory in rats with scopolamine-induced memory impairment. Cariprazine improved learning and memory in both short-term and long-term memory retention tests in step-down and step-through tasks. In T-maze and Y-maze cariprazine increased the working memory index as well as the percentage of spontaneous alternation. ![]() In NORT cariprazine increased the recognition index. Statistical analysis was performed with One Way ANOVA. intraperitoneally) in experimental rodent models with scopolamine-induced memory impairment employing novel object recognition test (NORT), T-maze, Y-maze, and passive avoidance tasks (step-through and step-down). We evaluated the pro-cognitive properties of 14-day long pre-treatment with cariprazine (0.25, 0.5, and 1 mg/kg b.w. ![]() Cariprazine is a novel antipsychotic conceived with the idea that high affinity for D3 receptors may elicit a favorable response in the management of cognitive deficits. Cognitive impairments do not generally respond to antipsychotics. The main symptoms of schizophrenia are categorized as positive, negative, and cognitive.
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